Pian Upe Game Reserve is located in far northern Uganda. Karamoja is the second-largest protected area after Murchison Falls National Park in northern Uganda. Although Pian Upe is beautiful, raw, pristine, and less visited, Pian Upe covers an area of about 2,788 sq. km.

Pian Upe  game reserve got its name from a local Karamojong word that means "friendly enemy." Pian Upe Game Reserve has hot springs and mercury walls like Mount Kadam, which make it an incredible destination for tourism activities.

Pian Upe wildlife reserve is within the Mount Elgon Conservation Area (MECA). This area is semi-arid, with heavy rainfall in April and lighter rainfall from June to early September each year. Most parts of the Pian Upe are occupied by short grassland.

Pian Upe is home to several species of wildlife, such as lions, giraffes, the Harte beast, buffaloes, greater Kudu, topis, antelopes, Oribi, and Rothschild’s giraffe. Bird species here include Jackson’s Hornbill,  white-headed buffalo –waver, Ostrich, Hartlaub’s Bustard, and  primate species like  olive baboons, vervet monkeys, with all mentioned above makes Pian Upe a great destination for an Uganda Safari